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CURRICULUM VITAE
Date: March, 2013
A. Personal Information
센터장소개
Name : Cheol Soo Choi M.D. Ph.D.
Current Position: Professor, Director of KMMPC & NECMD
Current Address : Korea Mouse Metabolic Phenotyping Center(KMMPC)
Lee Gil Ya Cancer and Diabetes Institute,
Gachon University, Incheon, Korea
Tel : (office) 032-899-6076
Fax : (office) 032-899-6077
E-Mail: cschoi@gachon.ac.kr, cheolsoo.choi@yale.edu
B. Professional Experience
  • 2010~present Director of National Efficacy Evaluation Center for MetabolicDiseases Therapeutics
    (NECMD, 국가지정 대사성질환 약리효능 평가센터)
  • 2007~present: Director of Korea Mouse Metabolic Phenotyping Center(KMMPC, 한국마우스 대사질환 특화센터).
  • 2007~2013 Associate Professor, Gil Medical Center, Gachon University of Medicine and Science
  • 2008~present: Consultant doctor of the Yale-NIH Mouse Metabolic Phenotyping Center. Yale University School of Medicine, New Haven, CT, USA
  • 2005~2008: Director of the Integrative Physiology Core of the Yale-NIH Mouse Metabolic Phenotyping Center. Yale University School of Medicine, New Haven, CT, USA
  • 2005~ 2007: Associate Research Scientist, Endocrinology, Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
  • 2005~ 2007: Associate Research Scientist, Endocrinology, Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
  • 2003.~2005:Visiting professor, Endocrinology, Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
  • 2000.~2005:Assistant Professor, Endocrinology and Metabolism,HallymUniversity Medical School, Anyang, Kyonggi , Korea
  • 1997~2000 Research Associate/Post-Doctoral Fellow, Physiology and Biophysics, University of Southern California, Keck School of Medicine, LosAngeles, California, USA
  • 1995~1997 Clinical Fellow , Endocrinology and Metabolism, Asan Medical Center, Ulsan University Medical school, Seoul, Korea
C. Education
  • 1995 ~ 1999
    • Department of Internal Medicine,
    • Pusan National Univ. Pusan, Korea
    • Degree conferred: Ph.D
  • 1991 ~1993
    • Department of Internal Medicine,
    • Pusan National Univ. Pusan, Korea
    • Degree conferred: M.S.
  • 1981 ~ 1987
    • College of Medicine, Pusan National Univ. Pusan, Korea
    • Degree conferred: M.D.
D. Postgraduate Training
  • 3/1987 ~ 2/1988 Intership Pusan National Univ. Hospital, Pusan, Korea
  • 5/1991~ 2/1995 Medical Residency Pusan National Univ. Hospital, Pusan, Korea
  • 3/1995 ~ 2/1997 Clinical Fellowship in Endocrinology & Metabolism, Asan Medical Center, Seoul, Korea
H. Publications
  • 70. Kim KH, Jeong YT, Oh H, Kim S, Cho JM, Kim Y, Kim SS, Kim DH, Hur KY,
    Kim HK, Ko TH, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh1N, Choi CS* & Lee M*. Autophage deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a ‘mitokine’. Nat Medicine 19:83-93, 2013 * contributed equally
  • 69. Lee KM, Yang SJ, Kim YD, Choi YD, Nam JH, Choi CS, Choi HS, Park CS. Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high fat diet-induced obesity and insulin resistance in mice. Diabetes. 2013 Jan 24. [Epub ahead of print]
  • 68. Huh JY, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB.A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells. Mol Cell Biol. 33(2):328-39, 2013
  • 67.Oh KJ, Park J, Kim SS, Oh H, Choi CS, Koo SH. TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver. PLoS Genet. 8(9):e1002986, 2012
  • 66. Lee YS, Park MS, Choung JS, Kim SS, Oh HH, Choi CS, Ha SY, Kang Y, Kim Y, Jun HS. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia. 55(9):2456-68, 2012
  • 65. Choi CS, Kim MY, Han K, Lee MS. Assessment of β-cell function in human patients. Islets 4(2):79-83, 2012
  • 64. Lee SY, Kim JR, Hu Y, Khan R, Kim SJ, Bharadwaj KG, Davidson MM, Choi CS, Shin KO, Lee YM, Park WJ, Park IS, Jiang XC, Goldberg IJ, Park TS. Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction. J Biol Chem. 287(22):18429-39, 2012
  • 63. Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 61(4):877-87, 2012
  • 62. Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS. Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response. Endocrinology. 153(4):1817-26, 2012
  • 61. Marimuthu M, Park C, Kim S, Choi CS. Real-time electrical measurement of L929 cellular spontaneous and synchronous oscillation. Int J Nanomedicine. 7:83-92, 2012
  • 60. Liu W, Singh R, Choi CS, Hui-Young L, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. LDL Receptor Related Protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J Biol Chem. 287(10):7213-23, 2012
  • 59. Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Dong HH, Kim YB, Kaneki M. Liver-specific iNOS expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem. 286(40):34959-75, 2011
  • 58. Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, Shulman GI. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology. 7(12):4109-19, 2011
  • 57. Shin HJ, Park YH, Kim SU, Moon HB, Park DS, Han YH, Lee CH, Lee DS, Song IS, Lee DH, Kim M, Kim NS, Kim DG, Kim JM, Kim SK, Kim YN, Kim SS, Choi CS, Kim YB, Yu DY. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem. 286(34):29872-29881, 2011
  • 56. Ryu D, Seo WY, Yoon YS, Kim YN, Kim SS, Kim HJ, Park TS, Choi CS*, Koo SH*. Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance. Diabetes 60(4):1072-81, 2011 * contributed equally
  • 55. Chang ZQ, Lee SY, Kim HJ, Kim JR, Kim SJ, Hong IK, Oh BC, Choi CS, Goldberg IJ, Park TS.endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2. Prostaglandins Other Lipid Mediat. 94(1-2):44-52, 2011
  • 54. Jongin Hong, Karthikeyan Kandasamy, Mohana Marimuthu, Cheol Soo Choi and Sanghyo Kim. Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study. Analyst 136(2), 237–245, 2011
  • 53. Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab. 12(6):668-674, 2010
  • 52. Choi CS • Ghoshal P • Srinivasan M• Kim S• Cline G• Patel MS. Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity. Lipids 45(11): 987-995, 2010
  • 51. Yoon YS, Lee MW, Ryu D, Kim JH, Ma H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy MR, Koo SH. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc Natl Acad Sci USA, 107(41): 17704-17709, 2010
  • 50.Srinivasan M, Choi CS, Ghoshal P, Pliss L, Pandya JD, Hill DJ, Cline GW, Patel MS. Beta cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. AM J Physiol Endocrinol Metab. 299(6):E910-917, 2010
  • 49. Zhang D, Christianson J, Liu ZX, Tian L, Choi CS, Neschen S, Dong J, Wood PA, Shulman GI. Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab. 11(5):402-411 2010
  • 48. Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, Hong S, Park KG, Lee IK, Choi CS, Hanson RW, Choi HS, Koo SH. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell metab. 11(4):331-339 2010
  • 47. Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling Protein-2 Decreases the Lipogenic Actions of Ghrelin. Endocrinology 151 (5): 2078-2086, 2010
  • 46. Won JC, Park JY, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn JH, Lee KU. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 30(2):290-7, 2010
  • 45. Kandasamy K, Choi CS, Kim S. An efficient analysis of nanomaterial cytotoxicity based on bioimpedance. Nanotechnology. 21(37):375501, 2010
  • 44. Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci USA, 106(52): 22510-22515, 2009
  • 43. Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwarts GJ, Zhang Y, Goldberg IJ, Yu YH. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes 58:2516-2524, 2009
  • 42. Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 9(3)240-251, 2009
  • 41. Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass FosB transgenic mice. Endocrinology 150(1):135-143, 2009
  • 40. Wang H, Knaub LA, Jensen DR, Jung DY, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Choi CS, Shulman GI, Kim JK, Kim JK, Friedman JE, Eckel RH. Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues. Diabetes 58(1):116-124, 2009
  • 39. Lee HJ, Lee YH, Park SK, Kang ES, Kim HJ, Lee YC, Choi CS, Park SE, Ahn CW, Cha BS, Lee KW, Kim KS, Lim SK, Lee HC. Korean red ginseng (Panaz ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism 58(8):1170-1177, 2009
  • 38. Cheol Soo Choi, Roberto Codella, Douglas E. Befroy, Sheene Kim, Richard M. Reznick, Yu-Jin Hwang, Zhen-Xiang Liu, Hui-Young Lee, Alberto Distefano, Varman T. Samuel, Dongyan Zhang, Gary W. Cline, Christoph Handschin, Jiandie Lin, Kitt F. Petersen,Bruce M. Spiegelman and Gerald I. Shulman. Paradoxical Effects of Increased Expression of PGC-1α on Muscle Mitochondrial Function and Insulin Stimulated Muscle Glucose Metabolism. Proc Natl Acad Sci USA, 105(50): 19926-19931, 2008
  • 37. Matthew P. Gillum, Xian-Man Zhang, Dongyan Zhang, Derek M. Erion,
    Rachel A. Jamison, Cheolsoo Choi, Jianying Dong, Marya Shanabrough,
    Hillary R. Duenas, David W. Frederick, Jennifer J. Hsiao, Tamas L. Horvath,
    Katie Carey, Pat Tso, Gary W. Cline, Gerald I. Shulman. N-acylphosphatidylethanolamine , a gut-derived circulating factor induced by fat ingestion, inhibits food intake. Cell 135(5):813-824, 2008
  • 36. Cheol Soo Choi*, Josep A. Villena*, Yuhui Wang, Sheene Kim, Yu-Jin Hwang,
    Young-Bum Kim, Gary Cline, Gerald I. Shulman and Hei Sook Sul. Resistance to high fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing Pref-1: a new model of partial lipodystrophy. Diabetes 57(12):3258-66, 2008 * contributed equally
  • 35. M. Faadiel Essop, Heidi S. Camp, Cheol Soo Choi, Saumya Sharma, Ryan M. Fryer, Glenn A. Reinhart, Patrick H. Guthrie, Assia Bentebibl, Zeiwei Gu, Gerald I. Shulman Heinrich Taegtmeyer, Salih J. Wakil and Lutfi Abu-Elheiga . Reduced Heart Size and Increased Myocardial Fuel Substrate Oxidation in ACC2 Mutant Mice. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H256-65.
  • 34. David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, and Anna A DePaoli-Roach. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. Plos Med 5(1):e27, 2008
  • 33. Nika N Danial, Loren D Walensky, Chen-Yu Zhang, Cheol Soo Choi, Jill K Fisher, Anthony J A Molina, Sandeep Robert Datta, Kenneth L Pitter, Gregory H Bird, Jakob D Wikstrom, Jude T Deeney, Kirsten Robertson, Joel Morash, Ameya Kulkarni, Susanne Neschen, Sheene Kim, Michael E Greenberg, Barbara E Corkey, Orian S Shirihai, Gerald I Shulman, Bradford B Lowell & Stanley J Korsmeyer. Dual Role of Pro-apoptotic BAD in Insulin Secretion and β-Cell Survival. Nat Medicine 14: 144-153, 2008
  • 32. Cheol Soo Choi, David Savage, Lufti Abu-Elheiga, Zhen-Xiang Liu, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Richard M. Reznick, Roberto Codella, Dongyan Zhang, Gary W. Cline, Salih J. Wakil, Gerald I. Shulman. Continuous fat oxidation in Acetyl-CoA carboxylase 2 mutant mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 104(42): 16480-16485, 2007
  • 31. Cheol Soo Choi, Jonathan J. Fillmore, Jason K. Kim, Zhen-Xiang Liu,
    Sheene Kim, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Mario Kahn, Yan Chen, Chunli Yu, Irene K. Moore, Richard M. Reznick, Takamasa Higashimori, Emily F. Collier, Gerald I. Shulman. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest, 117:1995-2003, 2007
  • 30. Dongyan Zhang, Zhen-Xiang Liu, Cheol Soo Choi,, , Liqun Tian,, Richard Kibbey, Jianying Dong, Gary W. Cline, Philip A. Wood, Gerald I. Shulman. Mitochondrial Dysfunction due to long-chain Acyl-CoA Dehydrogenase Deficiency Causes Hepatic Steatosis and Hepatic Insulin Resistance. PNAS. 104:17075-17080, 2007
  • 29. Robert V. Farese, Mini P. Sajan, Hong Wang, Pengfei Li, Steven Mastorides, William R. Gower, Jr., Sonali Nimal, Cheol Soo Choi, Sheene Kim, Gerald I. Shulman, C. Ronald Kahn, Ursula Braun, and Michael Leitges. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest, 117(8):2289-2301, 2007
  • 28. Christoph Handschin, Cheol Soo Choi, Sherry Chin, Sheene Kim, Dan Kawamori, Amamath J. Kurpad, Nicole Neubauer, Jiang Hu, Fenfen Liu, Eleftheria Maratos-Flier, Vamsi K. Mootha, Young-Bum Kim, Rohit N. Kulkarni, Gerald I. Shulman, and Bruce M. Spiegelman. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice through skeletal muscle-pancreatic cell cross-talk. J Clin invest 117(11):3463-3474, 2007
  • 27. Cheol Soo Choi, David B. Savage, Ameya Kulkarni, Xing Xian Yu, Zhen-Xiang Liu, Katsutaro Morino, Sheene Kim, Alberto Distefano, Varman T. Samuel, Susanne Neschen, Dongyan Zhang, Amy Wang, Xian-Man Zhang, Mario Kahn,Gary W. Cline, Sanjay K. Pandey, John G. Geisler, Sanjay Bhanot, Brett P. Monia, Gerald I. Shulman. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. JBC , 282(31):22678-88, 2007
  • 26. Qingchun Tong, ChianPing Ye, Rory J. McCrimmon, Harveen Dhillon, Brian Choi, Melissa Kramer, Jia Yu, Zongfang Yang Lauryn Christiansen, Siobhan kowronek, Charlotte Lee, Cheol Soo Choi, Jeffrey M. Zigman, Gerald I. Shulman, Robert Sherwin, Joel K. Elmquist and Bradford B. Lowell1. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 5(5):383-393, 2007
  • 25. Jonathan B. Hurov, Mei huang, Lynn S. White, Cheol Soo Choi, You-Ree Cho, Hyo-Jeong Kim, Julie L. Prior, David Piwnica-Worms, Lewis C. Cantley, Jason K. Kim, Gerald I. Shulman and Helen Piwnica-Worms. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. PNAS, 104: 5680-5685, 2007
  • 24. Qian Gao, Gabor Mezei, Yan Rao, Cheol Soo Choi, Ingo Bechmann, Csaba Leranth, Dominique Torran-Allerand, Catherine A. Priest, James L. Roberts, Xiao-Bing Gao, Charles Mobbs, Gerald I. Shulman, Sabrina Diano, and Tamas L. Horvath. Anorectic estrogen mimics leptin’s effect on the re-wiring of melanocortin cells and stat3 signaling in obese animals. Nat Medicine. 2007;13(1):89-94
  • 23. Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Stefan K, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman G, Spiegelman B, Lowell BB. Hypomorhphic Mutation in PGC1 causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006, 4(6):453-64.
  • 22. Alon M. Chen, Bhawanjit K. Brar, Cheol Soo Choi, David Rousso, Joan M. Vaughan, Yael Kuperman, Shee Ne Kim, Cindy Donaldson, Sean M. Smith, Chien Li, Tim R. Nagy, Gerald I. Shulman, Kuo-Fen Lee, Wylie W. Vale. Urocortin 2 mediates glucose utilization and insulin sensitivity in skeletal muscle. PNAS, 103(44):16580-5, 2006
  • 21. Wu JJ, Roth RJ, Anderson EJ, Hong E, Lee M, Choi CS, Neufer D, Shulman GI, Kim JK, Bennett AM: Mice Lacking Mitogen-Activated protein(MAP) Kinase Phosphatase-1 have Enhanced MAP Kinase Activity and Resistance to Diet-Induced Obesity. Cell Metabolism, 4(1):61-73, 2006.
  • 20. Cheol S. Choi*, Varman T. Samuel*, Trevor G. Phillips, Antony J. Romaneli, John G. Geisler, Sanjay Bhanot, Robert McKay, Brett Monia, John R. Shutter, Richard A. Lindberg, Gerald I. Shulman and Murielle M. Veniant: Targeting Foxo1 in mice using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action. Diabetes 55:2042-2050, 2006. * contributed equally
  • 19. Cheol S. Choi* , David B. Savage*, Varman T. Samuel, Zhen-Xiang Liu, Dongyan Zhang, Amy Wang, , Xian-Man Zhangi, Gary W. Cline, Xing Xian Yu, John G. Geisler, Sanjay Bhanot, Brett Monia, Gerald I.Shulman. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. Journal of Clinical Investigation 116(3):817-824, 2006 * contributed equally
  • 18.Stefan Bilz, Varman Samuel, Katsutaro Morino, David Savage, Cheol Soo Choi and Gerald I. Shulman: Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. Am J Physiol Endocrinol Metab 290:E716-E722, 2006
  • 17. Noboru Furukawa, Pat Ongusaha, Wan Jin Jahng, Kazushi Araki, Cheol S. Choi, Hyo-Jeong Kim, Kazushi Araki, Yong Hee Lee, Kozo Kaibuchi, Barbara B Kahn, Hiroaki Masuzaki, Jason K Kim, Sam W Lee and Young-Bum Kim: Role of Rho-kinase in Regulation of Insulin Action and Glucose Homeostasis. Cell Metabolism 2:119-129, 2005
  • 16. Susanne Neschen, Katsutaro Morino, Linda E. Hammond, Dongyan Zhang, Anthony J. Romanelli, Gary W. Cline, Zhen-Xiang Liu, Cheol Soo Choi, Rosalind A. Coleman, and Gerald I. Shulman : Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knock out mice. Cell Metabolism 2:55-65, 2005
  • 15. Cheol S. Choi, Young B. Kim, Felix N. Lee, Barbara B. Kahn, and Jang H. Youn: Lactate Induces Insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab 283 : E233-E240, 2002
  • 14. Cheol S. Choi, Felix N. Lee, Alicia A. McDonough and Jang H. Youn:
    Independent Regulation of In Vivo Insulin Action on Glucose versus K+
    Uptake by Dietary Fat and K+ Contents. Diabetes 51(4):915-920, 2002
  • 13. Chul-Hee Kim, Joong Y. Park, Jin Y. Kim, Cheol S. Choi, Young I. Kim, Yun E. Chung, Moo S. Lee, Sung K. Hong, Ki-Up Lee: Elevated Serum Ceruloplasmin Levels in Subjects With Metabolic Syndrome: A Population-Based Study. Metabolism 51(7):838-842, 2002
  • 12. Kyong Soo Park, Ki-Up Lee, Ji Hyun Song, Cheol Soo Choi, Chan Soo Shin, Do Joon Park, Suk Kyeong Kim, Jae Joon Koh, Hong Kyu Lee: Peripheral blood mitochondrial DNA content is inversely correlated with insulin secretion during hyperglycemic clamp studies in healthy young men. Diabetes Res Clin Pract. 52:97-102, 2001
  • 11. Cheol S. Choi, Felix N. Lee, and Jang H. Youn: Free Fatty Acids Induce Peripheral Insulin Resistance without Increasing Muscle Hexosamine pathway Product Levels in Rats. Diabetes 50:418-424, 2001
  • 10. Cheol S. Choi, Curtis B. Thompson, Patrick K. Leong, Alicia A. McDonough , and Jang H. Youn : Short-term K+ deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K+ clamp. Am J Physiol Renal Physiol 280 : F95-F102, 2001
  • 9. Y.I. Kim, C.-H. Kim, C.S. Choi, Y.E. Chung, M.S. Lee, S.I. Lee, J.Y. Park, S.K. Hong, K-U. Lee: Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population. Diabetes Res Clin Pract. 52:145-152, 2001
  • 8. C.S. Choi, C. Kim, W.J. Lee, J.Y. Park, S.K. Hong, M.G. Lee, S.W. Park, K. Lee. Association between birth weight and insulin sensitivity in healthy young men in Korea: role of visceral adiposity. Diabetes Res Clin Pract. 49(1):53-59, 2000
  • 7. Joong-Yeol Park, Young I. Kim, Cheol S. Choi, Yun E. Chung, Sang-Wook Kim, Moo-Song Lee, Sang I. Lee, Sung K. Hong, Ki-Up Lee. Prevalence of Diabetes, Impaired Glucose Tolerance, and Impaired Fasting Glucose in a Rural Population of Korea, According to 1997 American Diabetes Association and 1985 World Health Organization Criteria. Diabetes Care 23(5):707-708, 2000
  • 6. Chul-Hee Kim, Young I Kim, Cheol S Choi, Joong Y Park, Moo S Lee, Sang-Il Lee, Ghi S Kim: Prevalence and risk factors of low quantitative ultrasound values of calcaneus in Korean elderly women.. Ultrasound in Med. & Biol. 26(1):35-40,2000 5. Jason K Kim, Cheol S. Choi, and Jang H. Youn: Acute effect of GH to induce peripheral insulin resistance is independent of plasma FFA and insulin levels in rats. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E742-E749, 1999
  • 4. Curtis B. Thompson, Cheolsoo Choi, Jang H, Youn, and Alicia A. McDonough:
    Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am. J. Physiol. 276 (Cell Physiol. 45): C1411-C1419, 1999
  • 3. C.S. Choi, C.-H. Kim,, W.-J. Lee, J.-Y. Park, S.-K. Hong, K-U. Lee: Elevated Plasma Pronsulin/Insulin Ratio is a Marker of Reduced Insulin Secretory Capacity in Healthy Young Men. Horm Metab Res 31:267-270, 1999
  • 2. Kyong Soo Park, Ji Hyun Song, Ki-Up Lee, Cheol Soo Choi, Jae Joon Koh, Chan Soo Shin, Hong Kyu Lee: Peripheral blood mitochondrial DNA content correlates with lipid oxidation rate during euglycemic clamps in healthy young men. Diabetes Res Clin Pract. 46:149-154, 1999
  • 1. Kim GS, Kim CH, Choi CS, Park JY, Lee K-U: Involvement of different second messengers in parathyroid hormone and interleukin-1-induced interleukin-6 and interleukin-1l production in human bone marrow stromal ceIIs. J Bone Min Res 12:896-902,1997